Early Ameloblasts (DnE)

Cells of the inner enamel epithelium located adjacent to the dental papilla mesenchymal cells, differentiate into early ameloblasts during the bell stage. Early ameloblasts differentiate into mature cells through pre-secretory and secretory stages. During the pre-secretory stage, the early ameloblasts differentiate and initiate synthesis of the enamel-related proteins. In the secretory stage, the matrix proteins accumulate extracellularly and the tooth crown is formed.