Microarray analysis of brain tissues from Huntington's disease patients

Microarray analysis of post-mortem brain tissue from subjects with Huntington's diseases was performed.  Genes differentially expressed in ventral head of the caudate nucleus of Huntington's disease donors (n=10) when compared to that of normal controls (n=10) were identified.

The cases were selected on the basis of a confirmed clinical and neuropathological diagnosis, including the exclusion of confounding pathologies.  Snap-frozen brain blocks were provided by various tissue banks within the BraiNet Europe (BNE) network. The respective control tissues were matched for age, post-mortem (PM) delay and brain region.

This study includes additional samples, which were not analyzed by LifeMap.