Microarray analysis of retina from age-related macular degeneration donors

Microarray analysis of retinal pigmented epithelium (RPE)-choroid complex samples, obtained from donors with age-related macular degeneration (AMD), compared to the controls.

177 samples from the macular or extramacular region of human RPE-choroids and 118 samples from the macular or extramacular region of human retina with no reported ocular disease, possible preclinical AMD or AMD were analyzed using a two-color universal reference design. The reference RNA was comprised of a 1:1 mixture of pooled RPE-choroid and retina RNA from normal and AMD eyes. Except for two samples, no replicates were performed.

This study includes additional samples that were not analyzed by LifeMap.