Basophil Progenitors (HBM)

The consecutive expression of two transcription factors, GATA-2 and C/EBPα, are thought to regulate the differentiation of progenitor cells to the basophil lineage. In addition, Runx1 has been shown to be important for such differentiation, as mice deficient in the distal promoter-derived Runt-related transcription factor 1 (P1-Runx1) show severe basophilopenia, indicating the requirement of P1-Runx1 for the specific development of basophils. GATA-1 was also shown to play a key role in the generation and function of basophils.