Mesenchymal Stem Cells (ZgPro)

The mesenchymal stem cells (MSCs) make up a significant sub-population of cells in the periosteum and are usually isolated form the tibia bone of the leg. Periosteum MSCs exhibit fibroblast-like morphology, that is maintained over many passages in vitro. Their shapes may be elongated, spindle-shaped, triangular, or cuboidal. Some studies have reported uniform morphology within the population, while others researchers were able to visually distinguish sub-populations of cells. Yet others have reported a more cuboidal or polyhedral morphology during early Pe-MSCs progression along chondrogenic or osteogenic lineages. Periosteum MSCs have potential for osteogenic, chondrogenic, adipogenic, and myogenic differentiation.