Lineage analysis of the early mouse gastrula has identified a population of about 40 cells (the early-gastrula organizer, EGO) in the posterior region of the embryo whose descendants colonize the typical node derivatives and the node itself. Like the node, this cell population expresses a comparable repertoire of organizer markers and can induce a secondary body axis when transplanted. However, the secondary axis remains incomplete, lacking the anterior-most neural structures of the fore- and midbrain regions.
These cells have been described in mouse. The human parallel has not been identified yet.
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent