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All in Vivo Cells > Cell Card
Inner Cell Mass
Inner Cell Mass

Inner Cell Mass Cells (ICM)

Just before the blastocyst implants into the uterine wall, the inner cell mass cells further diverge into epiblast and hypoblast layers. These cells are considered to be naive ground state omnipotent stem cells, with high clonogenicity, capability of forming chimeras and teratomas. These cells would typically have two activated X chromosomes in female embryos. The cells will eventually develop into two distinct cell types- epiblast and hypoblast cells giving rise to embryonic and extraembryonic structures, respectively.

GATA6 positive cells will become hypoblast and NANOG positive cells will become epiblast. In mouse development, ICM develops on E3.5.
CS3 - CS4
Embryonic Stem Cells, Embryoblast, ICM
Inner Cell Mass Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent