The pretubular aggregate enlarges and begins to differentiate into the renal vesicle, the most primitive and first recognized stage of nephron structuring. Molecular patterning divides the renal vesicle into proximal and distal regions. Late-stage renal vesicles fuse with the adjacent ureteric tip via a connecting segment.
The first stage of renal vesicle formation is characterized by the progression of the mesenchymal-epithelial transition (MET) phase, and transformation of the solid pretubular mesenchymal cell aggregates into roundish epithelial structures with a central lumen. These structures are termed renal vesicles.
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