Between E9.5-E15, the liver bud undergoes significant growth as it is vascularized and colonized by hematopoietic cells to become the primary site of fetal hematopoiesis. Hematopoietic cells emerging from the aorta‐gonadmesonephros (AGM) migrate to the fetal liver at around E10.
DPC 23 in humans refers to fetal liver colonization by hematopoietic stem cells (HSC) from the aorta-gonad-mesonephros (AGM). By 6-8 weeks of gestation, the liver becomes the primary source of blood cells (mainly erythropoietic cells); a role which declines in the sixth month of pregnancy.
The liver is colonized by cells from the yolk sac and (AGM).
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent