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LifeMap Discovery

Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine

All in Vivo Cells > Cell Card
Liver Lobule

Periportal Hepatocytes (LvL)

Periportal hepatocytes receive both nutrient-rich blood from the portal vein, and oxygen-rich blood via the hepatic artery, which contains circulating hormones. During glucose metabolism, periportal hepatocytes execute gluconeogenesis.

In the periportal regions, b-catenin activity, which is important for zonal gene expression in perivenous hepatocytes, is antagonized by adenomatous polyposis coli (APC). In mice, liver zonation is evident only in the first week following birth.
Prenatal - Postnatal
Periportal Hepatocytes
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent