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LifeMap Discovery

Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine

All in Vivo Cells > Cell Card
Islets of Langerhans

Alpha Cells (IsL)


Alpha cells are glucagon producing endocrine cells which reside in the Islets of Langerhans. In mice, the alpha cells are the first to mature, (as determined by immunofluorescence) and are detectable as early as E9.5 in the dorsal pancreatic bud and one day later in the ventral pancreatic bud.

In the pancreas the differentiation of endocrine cells is non-synchronous and lasts from the secondary transition period (which is the major time of endocrine cell differentiation) to the postnatal period.

E9.5 - Postnatal
Glucagon-Producing Cells
Alpha Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent