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EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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All in Vivo Cells > Cell Card
Pancreas
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Islets of Langerhans
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Alpha Cells (IsL)


Pnc.IsL.AlpCs

Alpha cells are glucagon-producing endocrine cells which reside in the Islets of Langerhans. In mice, the alpha cells are the first to mature and are detectable, as early as E9.5, in the dorsal pancreatic bud and one day later in the ventral pancreatic bud.

The a-cells are more common in the tail portion of the pancreas than in the head portion.


In the pancreas, the differentiation of endocrine cells is non-synchronous and lasts from the secondary transition phase (which is the primary stage of endocrine cell differentiation) to the postnatal phase.
E9.5 - Postnatal
Glucagon-Producing Cells, A-Cells
Alpha Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent