Primitive node cells are a group of specialized cells that migrate through the primitive node, which is located at the cranial end of the primitive streak, and give rise to the prechordal plate and notochordal process. The cells migrating most anteriorly form the prechordal plate, whereas those migrating most posteriorly form the notochordal process.
Primitive node cells are responsible for many signals, including Activin, Chordin, Nodal, and Shh. Shh later induces formation of the floorplate, somites and dorsal endoderm.
These cells are detected as of day 15 in humans
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent