Hematopoietic Stem Cells (Spl)

Hematopoietic stem cells (HSCs) are multipotent, myelolymphoid stem cells which serve as a source of hematopoietic cells. During embryogenesis , the spleen sustains hematopoietic capacity and HSCs circulating in the embryo colonize the spleen.The fate of the HSC progeny in the fetal splenic environment is myeloid. Although there are differences in hematopoiesis between the fetal liver and fetal spleen, there are virtually no phenotypic, functional, or gene expression differences between the HSCs in these organs.