This molecular abnormality also may be translated on the cellular scale: an abnormal hemoglobin can bring about a visible RBC deformity
All cells are sex-chromatin negative, and cells have only 45 chromosomes with an XO chromosomal complement
Usually due to nondisjunction in male gamete during meiosis
Cells have 47 chromosomes with a sex chromosomal complement of XXY type, and a sex chromatin body is seen in 80% of cases
Seen in 1 of 500 male births; caused by nondisjunction of the XX homologs
Patients are infantile with scanty menses and a degree of mental retardation
Have 2 sex chromatin bodies in their cells and are called "superfemale"
Some are of proven fertility, and offspring may be normal