Human neonatal dermal fibroblasts (Dermagraft) (Organogenesis)

Human neonatal dermal fibroblasts are cultured in vitro. At passage 8, they are placed on a bioabsorbable mesh. As they proliferate across the mesh, they secrete human dermal collagen, matrix proteins, growth factors, and cytokines to create a three-dimensional human dermal substitute containing metabolically active, living cells.