Hematopoietic Stem Cells (AGM)

Hematopoietic stem cells (HSC), which are generated within the aorta-gonad-mesonephros (AGM) region, are multipotent,  myelo-lymphoid stem cell. These cells serve as a definitive source for hematopoietic cells that migrate and colonize the fetal liver (liver bud) at ~E10. Although controversy exists regarding the identity of the ancestor cell, there is evidence that these cells bud from endothelial cells of the ventral wall of the dorsal aorta.