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Endocrine progenitor cells are multipotent cells that develop into the different endocrine cell types (alpha, beta, delta, pancreatic polypeptide, epsilon and G cells). These cells express markers, such as Neurog3, distinct to the endocrine precursor fate.
Neurog3+ cells are detectable over a broad range of developmental stages during pancreas development in the mouse. They are first detectable in the dorsal pancreas at around E8.5 and at about E10.5 in the ventral pancreas, marking the initiation of endocrine fate specification. Neurog3 expression peaks at around E15.5, after which expression drops to barely detectable levels by birth.