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EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
Content

Welcome to
LifeMap Discovery

Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine

All in Vivo Cells > Cell Card
Pancreas
>
Dorsal Pancreatic Bud
>

Pancreatic Progenitor Cells (DPB)


Pnc.DPB.PncPCs

The pancreatic progenitor cells are the common ancestor of all the pancreatic cell types including the duct, exocrine and endocrine cells. The progenitors of the dorsal pancreatic bud will give rise to the cells of the anatomical compartments that develop from the dorsal bud (neck, body, tail and parts of the head of the mature pancreas). Initially located at diverse locations throughout the pancreatic tissue, these cells become localized to "tip" locations of the developing acinar-duct morphology and are then known as multipotent tip cells, where they retain their wide differentiation potential, although there are indications that later in development they lose the ability to become duct cells (which are differentiated from multipotent "trunk" cells which are also endocrine progenitors)

E9.5 - Postnatal
multipotent tip cells
Pancreatic Progenitor Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent