LifeMap Discovery® Version 1.8 with expression data for diseased Tissue and Cells
The new release includes high throughput experiment data for diseased tissues and cells. Experiments were manually curated and analyzed from the gene expression omnibus (GEO), scientific literature and large scale datasets and are available for > 80 diseases. Each disease experiment card provides information about the experimental samples, gene expression comparisons of diseased tissue vs. normal tissue, and relevant reference. This data is also now available in GeneAnalytics – our Gene Set Analysis tool, and in MalaCards – the Human Disease Database.
LifeMap Disocvery® Version 1.7 with data for Astrocytes lineage and updated information for Kidney, Pancreas, Bone and Cartilage
The new version includes: Astrocytes lineage ; Updates to Kidney, Pancreas, Bone and Cartilage (from somite & neural crest) lineages ; 19 new high-throughput experiments for: hair, tooth, early embryo, cornea, lens and astrocytes ; New data from Bodymap & RNAseq ; 40 new protocols, including 7 new categories of direct reprogramming protocols added ; ~60 new patient-derived iPSCs ; Family cell descriptions for BM-MSCs, Adipose-derived MSCs and UC-MSCs (tissue) and 50 new cell therapies, including 7 cards of marketed cell-based products. Additionally, The UCB-MSCs (blood) cell family was split into tissue and cord blood with full elaborate descriptions.
LifeMap Discovery® Version 1.6 with Tissue Specific, Fully Annotated Summaries of Gene Expression
The new release includes: Comprehensive list of genes expressed in a variety of organs / tissues and their related anatomical compartments,
in vivo and in vitro cells ; Improved GeneAnalytics matching score ; New gene expression data for tooth and blood,
RNA sequencing data from the Human Protein Atlas, and new microarray experiments for several organs and anatomical compartments ;
Updated development paths for cornea and lens development and early endoderm development ;
New differentiation protocols for renal cells and keratinocytes ; New in vitro cells including dental pulp stem cells and pluripotent naïve cells ;
Disease iPSC modeling for Huntington’s disease, pigmentosa and Fanconi’s anemia ; New and updated cell therapy applications.
LifeMap Discovery® v1.5 with GeneAnalytics™ released
The new release includes: GeneAnalytics, an interactive tool for gene expression analysis that applies a novel algorithm to match gene sets to tissues,
anatomical compartments and cells ; New "disease cards" including cell therapy approaches ; Improved display of developmental signals ;
Updated developmental paths for Epidermis, Oligodendrocytes, Schwann cells, Blood cells and adult mesenchymal stem cells (MSCs) ;
77 new differentiation protocols ; 126 new in vitro cells ; 96 new cell therapy applications and 45 new high throughput experiments and large scale datasets
including integration with GNF BioGPS and an exclusive dataset of a cultured cell collection.
Public release of LifeMap Discovery™ version 1.2
The new release includes extensive, detailed searchable information on more than 250 stem cell-based therapeutic approaches in research,
preclinical, clinical stages as well as marketed products, available via Premium access; high throughput experiments from MGI,
GENSAT and Hudsen in addition to already existing Euroexpress, GUDMAP, Human protein atlas, Homer, Tiger, Barcode and experiments
extracted from the literature and GEO; the addition of related stem cells, differentiation protocols and cell therapies to organs and tissue cards;
coverage of the development of the dermis; grouping of in vitro cells with common origin, mode of derivation and/or molecular characteristics;
and more comprehensive coverage of differentiation protocols.
Publication of Research Report Describing LifeMap Discovery™
The LifeMap Discovery product has been documented in a published paper authored by LifeMap Sciences’ research and development team.
The publication titled “LifeMap Discovery™: The embryonic development, stem cells, and regenerative medicine research portal”
is available via the open access peer-reviewed journal PLOS ONE and can be viewed via the link http://dx.plos.org/10.1371/journal.pone.0066629.
The publication describes the scientific and technological foundations of LifeMap Discovery, the first road map of cellular embryonic development.
For our complete press release, click here.
Public release of LifeMap Discovery™ version 1.1
The new release includes significant additions to our comprehensive in-vivo embryonic developmental paths, which describe differentiation
of cells from their early ancestors (primary progenitors) to specific cell fates. It also includes information on new progenitor and primary
cells and annotated cell differentiation protocols. Notably, it includes information for cells involved in diseases, such as Parkinson’s
disease and Age Related Macular Degeneration, both desired targets for cell therapy using dopaminergic neurons and retina cells, respectively.
In addition, the new version includes a large number of genes relevant to mapped developmental paths and stem cells, enabling researchers to
discover cellular and anatomical context of thousands of genes by using the powerful LifeMap Discovery™ gene search engine.
Public release of LifeMap Discovery™ version 1.0
We are pleased to announce the public release of LifeMap Discovery™ version 1.0. LifeMap Discovery is a state-of-the-art roadmap
of embryonic development and stem cell biology. The platform integrates embryonic development and stem cell biology with molecular,
cellular, anatomical and disease-related information, and provides data mining capabilities and bioinformatics applications.
LifeMap Discovery™ is a unique and powerful tool for research and discovery in multiple disciplines, including stem cell biology,
developmental biology, disease mechanisms and etiology, and drug and therapeutic discovery and development.