Rathke’s Pouch

The Rathke’s pouch is an ectodermal invagination of the roof of the developing embryonic mouth separated from the oral cavity by the cranial base. By E10.5, neural crest cells migrate back to the Rathke’s pouch, and partially surround it, creating a keyhole-shaped invagination at the caudal border of neural crest-derived cranial base tissues. It is the caudal border of neural crest-derived cranial base tissues.