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Progress Zone Cells (LB)


Lmb.LB.PZCs
Embryonic Development
Stem Cells & Regenerative Medicine
General
 Gene Expression(27) Stem, Progenitor & Primary Cells(0) Images(1)
 Cellular Markers(0) Protocol-derived Cells(0) Literature
 HT comparisons & samples(0) Diseases & Cell Therapies(0)
 Incoming Signals(4)
 Outgoing Signals(1)
 Developmental Ontology

Progress zone cells are rapidly proliferating, undifferentiated mesenchyme cells, situated directly underneath the Apical Ectodermal Ridge.

Prenatal
PZ, apical zone.
Progress Zone Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent

Gene Expression in
Progress Zone Cells

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Gene Expression (27)
Genes expressed, or selectively not expressed in the cell. The genes are manually curated from literature and/or imported from high throughput/large scale datasets. 

The manually curated genes can be identified by the Pubmed icon in the ‘Refs’ column.

Gene Symbol
Gene Distribution
Full Name
Expression
 
 
Localization
Method(s)
R/P
HT
ISH/IS
Refs
homeobox D10ISP
homeobox D9ISH, ISRP
Meis homeobox 1Transgenic MiceRP
Meis homeobox 2Transgenic MiceRP
msh homeobox 1ISH, ISRP
msh homeobox 2ISP
transcription factor AP-2, alphaISP
Fn1 (Fn-1)fibronectin 1
Alx4aristaless-like homeobox 4ISH, ISRP
bone morphogenetic protein 2
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Incoming Signals for
Progress Zone Cells

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Incoming Signals (4)
Signals that are received by the cell, or genes induced/inhibited by an unknown signal, are presented, along with their effect, source cell, signal transduction cascades, derived cells and relevant references. Signals are ordered by their outcome effect. 

Outgoing Signals of
Progress Zone Cells

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Outgoing Signals (1)
Secreted signals, along with their cell receivers as well as their reference
 
Name
Related Gene
HGFHgf

Developmental Ontology of
Progress Zone Cells

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Develops from (1)
Developmental ancestor(s) of the cell
Code
LPMCs
 
Develops to (3)
Developmental descendant(s) of the cell

Images Related to
Progress Zone Cells

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Literature related to
Progress Zone Cells

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References (7)
Bibliographic references, specifying the relevance of the citation, including links to PubMed
Relevance
Title
 
Journal
Year
Author
  • Main Source
  • Gene Expression
  • Signaling
Cellular interactions and signaling in cartilage development.Osteoarthritis Cartilage2000 DeLise AM et. al.
  • Development
  • Gene Expression
  • Signaling
Rethinking the proximodistal axis of the vertebrate limb in the molecular era.Genes Dev2007 Tabin C, Wolpert L.
  • Development
  • Signaling
Building limb morphology through integration of signalling modules.Curr Opin Genet Dev2009 Duboc V, Logan MP.
  • Development
  • Signaling
WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo.Cell2001 Kawakami Y et. al.
  • Gene Expression
Activator-inhibitor dynamics of vertebrate limb pattern formation.Birth Defects Res C Embryo Today2007 Newman SA, Bhat R.
  • Gene Expression
  • Signaling
Regulation of myogenic differentiation in the developing limb bud.J Anat2003 Francis-West PH et. al.
  • Signaling
The initiation of the limb bud: growth factors, Hox genes, and retinoids.Cell1995 Tabin C.
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