Tendon progenitor cells of the limb originate in the lateral plate mesoderm and are defined as Scleraxis-positive cells. In contrast to axial tendon formation, limb tendon progenitor cells are not localized within a specific compartment in the limb bud mesenchyme. Instead, they are intermingled with the migrating myoblasts in the dorsal and ventral parts of the limb bud. Scx-positive cells are first detected in the limb bud on E9.5 of the mouse embryonic development. The initial induction of Scx-positive cells is not dependent on signaling from muscle progenitor cells, but rather on signaling from the overlying limb surface ectoderm. The nature of this ectodermal signaling is still elusive.
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent