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Peripheral Nervous System
Peripheral Nerve Domain

Schwann Precursor Cells (PrND)

Schwann precursor cells (SPCs) are the stage between neural crest stem cells and Schwann cells. SPCs migrate with axons and provide essential trophic support to embryonic sensory and motor neurons. In addition, SPCs are essential for normal nerve fasciculation. A small fibroblast population found in the peripheral nerves is thought to develop from SPCs.

Most of the developmental data provided in the database for Schwann cells have been derived from research performed on Schwann cells located in or purified from a sciatic nerve, the largest and longest spinal nerve which begins in the lower back and runs through the buttock and down the lower limb.
E12 - E15
Schwann Precursor Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent