Reproductive System Development

Bipotential stage differentiation to the male and female genital system.

Top: At the bipotential stage, both Mullerian and Wolffian ducts are present.

Bottom left: In the male embryo, the Mullerian duct degenerates under the influence of AMH, secreted by the testicular Sertoli cell, and each testis connects to the Wolffian duct through a series of tubules. During further development, the Wolffian duct gives rise to the efferent ductules, epididymis, ductus deferens, ejaculatory duct, and the seminal vesicle under the control of androgens produced by Leydig cells.

Bottom right: In the female embryo, the Wolffian duct degenerates, while the Mullerian duct contributes to the formation of the female reproductive organs. The distal ends of the paired Mullerian ducts fuse to form the vagina and uterus. The proximal un-fused portions become the oviduct (Fallopian tubes).