Mesenchymal stem cell for meniscal regeneration after hemi-meniscectomy

Human bone marrow-derived mesechymal stem cells (BM-MSCs) were injected into the knee joint of a rat hemi-meniscectomy animal model. Although the number of injected hMSCs decreased with time, hMSCs enhanced meniscal regeneration, increased expression of rat type II collagen (rat-Col II), and inhibited progression of osteoarthritis.