EpiCel™, cultured keratinocytes for burns

Epicel® cultured epidermal autografts (CEA) is an aseptically processed wound dressing composed of autologous keratinocytes grown ex vivo in the presence of proliferation-arrested mouse fibroblasts for treating deep dermal or full-thickness burns comprising a total body surface area of greater than or equal to 30%. Epicel® consists of sheets of proliferative, autologous keratinocytes, ranging from 2 to 8 cell layers thick and is referred to as a cultured epidermal autograft. Each graft of Epicel® is attached to petrolatum gauze backing with stainless steel surgical clips and measures approximately 50 cm2 in area. In a 7-year study, the survival rate of patients treated with the CEA in addition to standard care was significantly higher compared to controls treated with standard care only.