Systemic Lupus Erythematosus

 - Cell Therapy Approaches

Hematopoietic stem cell transplantation can serve as an effective treatment for SLE. Immunoablative therapy is first initiated to eliminate or reduce the level of autoreactive T and B lymphocytes. Re-population of the bone marrow with transplanted hematopoietic stem cells then leads to the regeneration of de-novo immunity by resetting the autoreactive immune system to a self-tolerant, protective immune system, resulting in prolonged and treatment-free remission.