Mesenchymal Stem Cells (CrdB)

1. The presence of umbilical cord mesenchymal stem cells (MSCs) in cord blood (UCB) seems controversial: some researchers successfully isolated MSCs from UCB, whereas others failed to isolate them or obtained a low yield. 2. The in-vivo origin of umbilical cord mesenchymal stem cells in cord blood is still unclear. 3. Umbilical cord mesenchymal stem cells (UCMSCs) express markers such as OCT4, which enhances self-renewal and pluripotency. Additionally, they express human embryonic stem cell (hESC)-specific markers such as SSEA-4,Tra 1-60, Tra-81 and NANOG. Based on this expression profile, UCMSCs have the capacity to differentiate into cell lineages derived from any of the three germ layers. Interestingly, In-vitro cultured UCMSCs have a strong osteogenic differentiation potential and less adipogenic capacity, when compared to bone-marrow MSCs.