Cord blood mesenchymal stem cells (MSCs) represent the second-largest population of cord blood cells, after hematopoietic stem cells (HSCs). These MSCs are unique in that they display an intermediate phenotype that resembles human embryonic stem cell (hESC) pluripotency.
1. The presence of umbilical cord mesenchymal stem cells (MSCs) in cord blood (UCB)
seems controversial: some researchers successfully isolated MSCs from UCB, whereas others failed to isolate them or obtained a low yield.
2. The in-vivo origin of umbilical cord mesenchymal stem cells in cord blood is still unclear.
3. Umbilical cord mesenchymal stem cells (UCMSCs) express markers such as OCT4, which enhances self-renewal and pluripotency. Additionally, they express human embryonic stem cell (hESC)-specific markers such as SSEA-4,Tra 1-60, Tra-81 and NANOG. Based on this expression profile, UCMSCs have the capacity to differentiate into cell lineages derived from any of the three germ layers. Interestingly, In-vitro cultured UCMSCs have a strong osteogenic differentiation potential and less adipogenic capacity, when compared to bone-marrow MSCs.
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