The mesenchymal stem cells (MSCs) make up a significant sub-population of cells in the periosteum and are usually isolated form the tibia bone of the leg. Periosteum MSCs exhibit fibroblast-like morphology, that is maintained over many passages in vitro.
Their shapes may be elongated, spindle-shaped, triangular, or cuboidal. Some studies have reported uniform morphology within the population, while others researchers were able to visually distinguish sub-populations of cells. Yet others have reported a more cuboidal or polyhedral morphology during early Pe-MSCs progression along chondrogenic or osteogenic lineages. Periosteum MSCs have potential for osteogenic, chondrogenic, adipogenic, and myogenic differentiation.
1. The in vivo origin of these mesenchymal stem cells is putative
2. The periosteum may serve as an excellent source of cells for orthopedic tissue engineering and regenerative medicine.
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent