Bipolar cells are interneurons located in the inner nuclear layer (INL) of the retina, mainly in the center of the INL. They act, directly or indirectly (via amacrine cells), by transmitting signals from the photoreceptors to the ganglion cells. The Off cone bipolar cells show hyperpolarizing light responses. There are 5 types of Off cone bipolar cells, which differ in their dendritic branching pattern and the shape and stratification level of their axon terminals in the inner plexiform layer (IPL). In general, the axons of the Off cone cells terminate in the outer IPL.