Oligodendrocyte precursor cells (OPCs) are induced from neuroepithelial cells in defined regions within the ventral and dorsal ventricular zone of the spinal cord. The ventral OPCs originate from the motor neuron progenitor (pMN) domain that first produces motor neurons followed by oligodendrocyte precursor cells (OPCs). These cells undergo extensive proliferation and migrate throughout the developing white matter. When a sufficient number of progenitor cells have been generated, OPCs differentiate into pre-myelinating oligodendrocytes.
In mice, the spinal cord OPCs migrate out of the ventricular zone by E13.5.
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