Prominent Markers and Signals during Oligodendrocyte development

Prominent Markers and Signals during Oligodendrocyte development.

Signals and gene expression markers characteristic of developing oligodendrocytes derived from the spinal cord and the telencephalon. Signals are indicated alongside the icons representing their effect (see legend at the bottom of the image) and the gene expression markers are indicated in the center of the image, just below cell names.  

(A) Neuroepithelial progenitor cells within the spinal cord and the telencephalon differentiate into (B) oligodendrocyte precursor cells, which are proliferative and migratory cells that populate the spinal cord and forebrain white matter and later develop into (C) pre-myelinating oligodendrocytes, which mature to become (D) myelinating oligodendrocyte cells that synthesize myelin.