Embryonic Development | Stem Cells & Regenerative Medicine | General |
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HT comparisons & samples(43) | Stem, Progenitor & Primary Cells(33) | Images(2) |
Anatomical Compartments(3) | Differentiation Protocols(9) | Literature |
Cells(46) | Cell Therapies(51) | |
Diseases(4) | ||
Signals(36) | ||
Developmental Ontology |
Method | Experiment/ Large Scale Dataset | Gene Expression Comparison/ Large Scale Dataset Sample | Prenatal/ Postnatal | In vivo / In vitro | Related Card | |
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Microarray, EST | Large Scale Dataset: Homer | blood vessel | Postnatal | In vivo | Endothelium | |
Microarray | Large Scale Dataset: Barcode 430 2.0 | aorta | Postnatal | In vivo | Endothelium | |
Microarray | Large Scale Dataset: Barcode U133 Plus 2.0 | cd31+ cells | Postnatal | In vivo | Endothelium | |
Microarray | Large Scale Dataset: Barcode U133A | blood outgrowth endothelial cell | Postnatal | In vivo | Endothelium | |
Microarray | Large Scale Dataset: Barcode U133A | huvec | Postnatal | In vivo | Endothelium | |
Microarray | Large Scale dataset: Cultured Cell Collection | Human Aortic Endothelial Cells (HAEC) | Postnatal | In vitro | Endothelium | |
Microarray | Large Scale dataset: Cultured Cell Collection | Human Bladder Microvascular Endothelial Cells (HBdMEC) | Postnatal | In vitro | Endothelium | |
Microarray | Large Scale dataset: Cultured Cell Collection | Human Brain Microvascular Endothelial Cells (HBMEC) | Postnatal | In vitro | Endothelium | |
Microarray | Large Scale dataset: Cultured Cell Collection | Human Cardiac Microvascular Endothelial Cells (HCMEC) | Postnatal | In vitro | Endothelium | |
Microarray | Large Scale dataset: Cultured Cell Collection | Human Choroid Plexus Endothelial Cells (HCPEC) | Postnatal | In vitro | Endothelium |
Available Data | |||||
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Name | Synonyms | EIndex | Cells | Genes | High Throughput Gene Expression Comparisons and Large Scale Dataset Samples |
Veins | Endth.Vns | 2 | 19 | ||
Arteries | Endth.Art | 2 | 13 | ||
Microvessels | Endth.Mcr | 2 | 27 |
Available Data | ||||||||
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Name | Anatomical Compartment | Organ / Tissue | Developmental Path | Progenitor Status | Developmental Time | Genes | Signals | Diseases |
Hemangioblasts | Posterior Primitive Streak | Primitive Streak | Blood, Endothelium | E7 - E7.5 | 18 | 6 | ||
Extraembryonic Angioblasts | Extraembryonic Blood Islands | Extraembryonic Mesoderm | Endothelium | E7.5 - E8 | 14 | 1 | ||
Extraembryonic Angioblasts | Extraembryonic Capillary Plexus | Extraembryonic Mesoderm | Endothelium | E8.5 - E(N/A) | 213 | 1 | ||
Angioblasts | Septum Transversum Capillary Plexus | Mesoderm | Endothelium | Prenatal | ||||
Angioblasts | Foregut | Gut Tube | Endothelium | E8.5 - E(N/A) | 6 | |||
Pancreatic Endothelial Cells | Prepancreatic Dorsal Foregut Endoderm | Gut Tube | Endothelium | Prenatal | 1 | |||
Pancreatic Endothelial Cells | Prepancreatic Ventral Foregut Endoderm | Gut Tube | Endothelium | Prenatal | ||||
Angioblasts | Embryonic Blood Islands | Lateral Plate Mesoderm | Endothelium | E8.5 - E9.5 | 30 | 1 | ||
Angioblasts | Embryonic Capillary Plexus | Lateral Plate Mesoderm | Endothelium | Prenatal | 33 | 8 | ||
Angioblasts | Proepicardium | Lateral Plate Mesoderm | Endothelium | Prenatal | 13 | 3 |
Name | Type | Anatomical Compartment > Cell | Affected By | Potential Therapeutic Candidate | |
---|---|---|---|---|---|
Atherosclerosis Susceptibility | Arteries > Arterial Endothelial Cells | ||||
Hemangioma | Cardinal Veins > Venous Endothelial Cells | ||||
Lymphedema | Cardinal Veins > Venous Endothelial Cells | ||||
Human Venous Malformation | Veins > Vascular Smooth Muscle Cells |
Signals are listed according to their order of development from the first ancestor(s)
Name | Pathway | Outcome | Developmental Path | Affected Cells | Progenitor Status | Derived Cells |
---|---|---|---|---|---|---|
Notch1 - Low | Differentiation | Endothelium | Posterior Primitive Streak > Hemangioblasts | Embryonic Blood Islands > Angioblasts | ||
BMP4 | Differentiation | Endothelium | Posterior Primitive Streak > Hemangioblasts | |||
Notch1 - High | Differentiation | Endothelium | Posterior Primitive Streak > Hemangioblasts | Extraembryonic Blood Islands > Primitive Hematopoietic Stem Cells | ||
VEGF | Differentiation | Endothelium | Posterior Primitive Streak > Hemangioblasts | Extraembryonic Blood Islands > Extraembryonic Angioblasts Embryonic Blood Islands > Angioblasts | ||
VEGFA | Differentiation | Endothelium | Perineural Capillary Plexus > Angioblasts | Blood Brain Barrier > Endothelial Cells | ||
VEGF | Differentiation | Endothelium | Chorionic Villus > Extraembryonic Hemangioblast Cells | Chorionic Villus > Angioblasts | ||
TGFβ1 | Inhibition of Differentiation | Endothelium | Periocular Mesenchyme > Periocular Mesenchymal Cells | Corneal Endothelium > Endothelial Cells Corneal Stroma > Keratoblasts | ||
RA | Differentiation | Endothelium | Periocular Mesenchyme > Periocular Mesenchymal Cells | Corneal Endothelium > Endothelial Cells Corneal Stroma > Keratoblasts | ||
Sema3A | Endothelium | Periocular Mesenchyme > Periocular Mesenchymal Cells | ||||
S1P | Migration | Endothelium | Extraembryonic Capillary Plexus > Extraembryonic Angioblasts |
Name | EIndex | Anatomical Compartments | Cells |
---|---|---|---|
Extraembryonic Mesoderm | ExM | 4 | 9 |
Lateral Plate Mesoderm | LtPM | 15 | 18 |
Available Data | ||||||||
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Cell Type | Name | Provider | Genes | Protocols | Cell Therapies | Matched In Vivo Cells & Compartments | High Throughput Gene Expression Comparisons and Large Scale Dataset Samples | |
ASC | Genetically modified vein-derived endothelial cells | Multi Gene Vascular Systems (MGVS) | 4 | 1 | ||||
ASC | Peripheral blood-derived endothelial progenitor cells | Harvard University | 9 | 1 | ||||
ASC | eNOS-transfected endothelial progenitor cells | Ottawa Hospital Research Institute | 1 | 1 | ||||
ASC | Bone marrow-derived endothelial progenitor cells | University of Milan | 7 | 1 | ||||
ASC | Peripheral blood-derived endothelial progenitor cells | Zhejiang University | 4 | 1 | ||||
ASC | Peripheral blood-derived endothelial progenitor cells | University of Frankfurt | 3 | |||||
ASC | eNOS-transfected endothelial progenitor cells | Northern Therapeutics, Inc. | 1 | 1 | ||||
ASC | Peripheral blood-derived early endothelial progenitor cells | Queen's University Belfast | 2 | 1 | ||||
ASC | eNOS-transfected endothelial progenitor cells | Northern Therapeutics, Inc. | 3 | 1 | ||||
ASC | Peripheral blood-derived endothelial progenitor cells | Huazhong University of Science and Technology | 3 |
The cell therapies are designed either to treat diseases affecting this organ/tissue or to utilize cells related to this organ/tissue for treatment of diseases affecting other organs